Migraine is pervasive

Migraine is a global problem affecting  greater than 10% of the population (859 million globally).

More than 44 million individuals are affected in the USA.

The prevalence peaks in middle life during prime years of productivity.

The global prevalence is 15-25% women, and 6 -8% men (2-3 times more common in women than men).

Lifetime prevalence is 43% in women and 18% in men.

Migraine is disabling

Unfortunately, migraine attacks are usually associated with severe impairment or need for bed rest.

Migraine is a leading cause of years lived with disability worldwide.

Migraine is related to both nature and nurture

80% of patients have a first degree relative with migraine reflecting a genetic predisposition.

Specific gene variations and mutations have been identified that are linked to impacting neurotransmitter function and blood vessel regulation in the brain leading to development of migraine.

Genetic predisposition leads to a more hyperexcitable brain.

Hyperexcitability of the brain is further impacted by both endogenous and exogenous environmental factors.

These environmental factors dictate risk modulation and triggers impacting frequency of attacks and response to therapeutics.